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In the Methods, we explain why we take the multiplier, S , of the V max values of GCL and GPX to have the following dependence on estradiol, E 2: Thus, since male E 2 is 0.09 nM [26] , S = 1 for the male
In this way, supporting liver detoxification with glutathione may help break the chemical feedback loop that drives the debilitating symptoms of POTS and dysautonomia
Conflict of interest The author has provided advisory services to AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Merck Sharp & Dohme, and Novo Nordisk, and has received lecture honoraria from Bristol Myers Squibb, Novartis and the above-mentioned companies
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