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Assuming that stable mutant monomers are synthesized, up to seven different tetrameric forms of PK may be present in compound heterozygous individuals, each with distinct structural and kinetic properties
This reveals that Ringer solution primes erythrocytes for eryptosis and/or that iRPMI protects erythrocytes from eryptosis
Because apparent clearance was 3441% lower in the youngest/lightest children, a weight-based (mg/kg) regimen was selected to achieve comparable systemic exposure across all ages and weights and for getting the target (about 4073% across bands) compared to placebo
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