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This is because tirzepatide is not just a GLP-1 receptor agonist but also a GIP receptor agonist, making it more potent in some respects and potentially more likely to cause gastrointestinal side effects in the early weeks
Simple math with serious consequences
Any deviation from licensed dosing regimens should only occur under close medical supervision, as the risk-benefit profile at sub-therapeutic doses remains poorly characterised
Dosing must only follow the protocol of the specific authorised trial in which a participant is enrolled
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