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[135] Propionibacterium , the other commonly used bacteria, produce no exotoxins or endotoxins and are generally recognized as safe (have been granted GRAS status) by the Food and Drug Administration of the United States

The subcutaneous route is used at much smaller doses than oral because a 100 mg injection would require two 50 mg vials and about 6 mL of liquid when each vial is mixed with 3.0 mL BAC water, which is too much for one subcutaneous site

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What we have demonstrated here is that some patients with dementia have the potential to improve their brain functions and resting-state brain activities following NPTs and is largely consistent with previous studies investigating brain plasticity in older adults and patients at risk of dementia