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LKB1, a tumor suppressor, is a major mammalian AMPK kinase in the liver that activates AMPK by phosphorylating the Thr172 residues of AMPK subunits
Hepatology 54 , 21852197 (2011)
Injected forms bypass the digestive tract entirely, which allows a higher percentage of the dose to remain intact and biologically active compared to oral versions, since stomach acid and digestive enzymes can break down a portion of an oral dose before it ever reaches the bloodstream
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