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This fundamental action anchors the glucose-lowering efficacy of GLP-1 RAs and establishes their therapeutic relevance in diabetes management

Findings from other models of CNS degeneration, suggesting that normalization of the NADH/NAD + ratio promotes viability, support that this ratio (which is also a proxy for LPR) represents the connection between metabolic and inflammatory processes after injury [68, 69]

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However, because the studies differed considerably in how they measured these behaviors and the types of participants they enrolled, the authors caution that the pooled estimate should be interpreted carefully