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Despite headline-grabbing clinical results (up to 22% weight loss in trials), studies show average weight reduction in routine care is typically 28% after a year, with only about one third of patients achieving greater than 5% loss
In conclusion, the association between heparanase and endothelial damage is complex and is potentially modulated by calcium ions
It can also manifest as a general flushing of the face and neck or small, pinpoint red spots that may feel sensitive or warm to the touch
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