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Clinical trials have demonstrated an impressive average weight reduction of 15 to 20 percent with lifestyle changesan effectiveness hard to surpass

Cost Optimization Some users report stretching medication supply through microdosing: Extended pen life: Using lower total weekly doses during maintenance Shared supply: Some households with multiple users (controversial) Insurance gap coverage: Stretching doses during authorization delays Warning: Cost-motivated dose reduction may compromise efficacy

95% CI, 1.26-1.56), but shorter duration (=26 weeks) of treatment was not (RR 0.79)