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Animals The GCLM knockout (KO) mouse line (characterized previously 16 ) has been backcrossed into the C57BL/6J background for more than 10 generations

Signs to look out for include fatigue and lethargy, depression, irritability, headaches, difficulty with balance, decreased cognitive function, constipation, sore or swollen tongue, heart palpitations, mouth ulcers, pins and needles and changes to vision

Glucagon-receptor agonism is attractive because it can raise energy expenditure, potentially counteracting that adaptive slowdown and adding a second lever on the energy-balance equation

A breathalyzer measuring 0.09% BAC is a 0.09% BAC whether the driver ate a full dinner or nothing at all