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Nardo, A., Micali, G., & Drago, F
Key risk factors include age (over 50), vascular conditions like hypertension and diabetes, lifestyle factors such as smoking and obesity, untreated obstructive sleep apnea, and certain medications
GLP1 receptor activated insulin secretion from pancreatic cells: mechanism and glucose dependence
After a 4-week run-in period in which participants were treated with diet and exercise alone, those who fulfilled the randomisation criteria were randomised (1:1:1:1) using a web-based randomisation system to receive once-daily oral semaglutide 3 mg, 7 mg or 14 mg or placebo for 26 weeks (using a 4-week dose-escalation regimen for the higher doses)
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