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Drugs of abuse increase BBB permeability, which, in turn, increases influx of peripheral toxins into the brain
Most patients receive B12 shots once each week
Subsequent studies have supported the idea that PLEX can have positive effects on the modulation of the inflammatory response, organ function, and the cerebral metabolic rate of oxygen in patients with ALF, which could lead to improved clinical results and a decrease in the morbidity and mortality associated with the condition.56,57 In general, there is information on the potential benefit of high-volume PLEX, but more studies are needed to better define its role in the management of ALF
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