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As noted by experts at the University of Connecticut, GLP-1 peptide molecules are too large to effectively penetrate the skin barrier, making transdermal delivery of actual GLP-1 medications currently impossible with existing technology

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The FDA-approved versions of semaglutide are based on: Tons of clinical studies and research on real people Obtaining consistent results with each dose Stringent quality control measures that the manufacturer must comply with Clear instructions for usage Compounded versions of semaglutide: Are not FDA-approved Have a difference in quality between different pharmacies May not have the same mix of ingredients each time Do not have proof that they actually work (no validated efficacy data) Is compounded semaglutide safe

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