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Age-related changes in renal function, hepatic metabolism, and tissue perfusion theoretically could influence peptide clearance and distribution, though no studies have systematically examined age effects
In a study by Huang et al., in 2022, miR-134-5p was found to be upregulated in bronchopulmonary dysplasia (BPD) in preterm infants, leading to ROS and Fe 2+ accumulation and GPX4 downregulation in these patients
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