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Key secondary endpoints included non-inferiority of tirzepatide (5 mg) compared to insulin degludec in HbA1c reduction, superiority of all tirzepatide doses over insulin degludec in HbA1c reduction and weight loss, and the proportion of participants achieving an HbA1c level below 7.0% at week 52
Direct cartilage benefits and weight-related joint offloading are real and clinically significant
These mechanisms result in the downregulation of Bcl-2 and NF-B p65, alongside the upregulation of cleaved caspase-3/8 and Bax, ultimately inducing apoptosis in ovarian cancer cells [68]
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