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The development of hypertension caused by high salt intake is intimately linked to oxidative stress, which causes endothelial dysfunction that damages vascular tissue and consequently increases blood pressure (Reference Touyz, Rios and Alves-Lopes139)

Clinical Studies The efficacy of TRESIBA administered once-daily either at the same time each day or at any time each day in patients with type 1 diabetes and used in combination with a mealtime insulin was evaluated in three randomized, open-label, treat-to-target, active-controlled trials in adults and one randomized, open-label, treat-to-target, active-controlled trial in pediatric patients 1 year of age and older

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