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[11] Glutathione is maintained in the reduced form by an NADPH-dependent glutathione reductase and the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) generally exceeds a value of 7
12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.769.58;Emax: 9.918.90)
As discussed previously, a tentative example of selective effect would be modulation of S1PR2 in astrocytes, which seems to be linked to glutamate recycling and mitochondrial metabolism (116), both promising mechanisms to ameliorate excitotoxic synaptopathy
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