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It was discovered through research on the cochlear nucleus in the central auditory pathway that it reduced the expression of the protein kinase C gamma subunit (PKC) after noise exposure and increased the decrease of GABAB receptor 1 (GABABR1) and GABABR2
None of these endpoints has been validated against clinical outcomes for GLP-1R agonists specifically, and EVOKE is the cautionary case of how readily a biomarker shift and a clinical result can be conflated
