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The GLP-1 peptide (a short chain of amino acids) is secreted by cells in the small intestine, but it is also synthesized in the brain

GI AEs were detected most frequently, were transient and usually occurred with dose escalation

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Fortunately, ondansetron plus metoclopramide has shown efficacy in reducing nausea from GLP-1 initialization and ondansetron is frequently prescribed by physicians for patients initiating on GLP-1s

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