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Retatrutide is an investigational once-weekly triple agonist that targets GLP-1, GIP, and glucagon receptors
Phase 2 trials showed it was well-tolerated even at doses higher than typically used
Since semaglutide is a pure agonist of the GLP-1 receptor, it exclusively stimulates the phenomena controlled by this receptor, while the ability of tirzepatide to act simultaneously on the GLP-1 and GIP receptors enables the activation of all the processes mediated by these incretins (Figure 3)
Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance
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