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In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds

Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months

This is a significant finding, as it means participants taking AOD 9604 did not experience a higher rate of adverse effects than those taking a substance with no active ingredient

But it is the reason independent replication is the gap the rest of the literature has not yet filled