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The titration schedule tested across all trials was: Weeks 1-4: 2.5 mg once weekly Weeks 5-8: 5 mg once weekly Weeks 9-12: 7.5 mg once weekly (optional step) Weeks 13-16: 10 mg once weekly Weeks 17-20: 12.5 mg once weekly (optional step) Weeks 21+: 15 mg once weekly (maximum approved dose) No trial tested 1.25 mg twice weekly, 2.5 mg twice weekly, or any other split-dose protocol

Patients with pernicious anemia have about 3 times the incidence of carcinoma of the stomach as the general population, so appropriate tests for this condition should be carried out when indicated

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