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doi: 10.1172/jci.insight.97843 Summary Keywords obesity, high-fat, high-fructose diet, brown adipose tissue, type 2 diabetes mellitus, transcriptional analysis, semaglutide, tirzepatide Citation Ma T, Song F, Pan Y, He Y, Cao X, Zhang Y, Song G and Ren L (2025) Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet
In physiological terms, amylin is one of the bodys satiation signals: it acts alongside insulin to communicate that a meal has arrived and that ingestion should slow
Framing expectations around a process rather than a single target number tends to serve people better over time
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