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Pro-inflammatory actions of heme and other hemoglobin-derived DAMPs

Heavy drinkers metabolize alcohol faster through MEOS induction and CYP2E1 upregulation, but this increased clearance speed does not reduce impairment or protect the liver

Nov., Xc inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism, Cancer Lett

While some studies have not found a similar effect in Hepatitis B surface antigen (HBsAg)-seropositive patients regarding ALT levels, other research indicates an increased risk of cirrhosis in HBV carriers who smoke 20 or more cigarettes per day, an effect that is particularly pronounced when combined with habitual alcohol consumption [85, 86]