This altered gut permeability may negatively affect DAO production and release, contributing to an imbalance in histamine levels and exacerbating histamine intolerance symptoms
If A1C target is still not achieved after ;3 months of dual therapy, proceed to three-drug combination (Fig
Diabetologia 9:15411554 Funding This work was supported by grants from the National Natural Science Foundation of China (81801169, 81870952, 82001303, 82371255, 82071258), Shanghai Science and Technology Innovation Action Plan (23DZ2291500), Natural Science Foundation of Shanghai (24ZR1457100), Project of Shanghai Sixth Peoples Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (ynnkxyb202412), Program for Shanghai Outstanding Academic Leaders(23XD1402500), Program for Outstanding Medical Academic Leader of Shanghai (2022LJ011), and Training program for research physicians of innovative translational ability (SHDC2022CRD037)
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