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This sequential approach serves two purposes: first, to eliminate immortal time bias by properly aligning treatment initiation with follow-up start (T0) and, second, to maximize statistical power by allowing individuals to contribute data across multiple trials

You may be eligible if at least one of these is true: You have a Body Mass Index (BMI) of 35 or higher Your BMI is 30 or higher, and you have certain types of heart failure OR high blood pressurethats hard to control OR chronic kidney disease (stage 3a or above) Your BMI is 27 or higher, and you have prediabetes OR youve had a heart attack, stroke, orblocked arteries in your legs or arms Patients with type 2 diabetes, moderate-to-severe sleep apnea, or fatty liver disease should contact their Medicare drug plan, as they may already cover a GLP-1 drug outside of this program

doi: 10.1002/9781119597797.ch13 488 ZhaoYDongBRHaoQ