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Incretin-based medications, including GLP-1 receptor agonists like semaglutide (Wegovy) and the dual GIP/GLP-1 receptor agonist tirzepatide (Zepbound), promote weight loss through multiple mechanisms that influence body fat distribution
Risk may be considered high in early treatment or dose-escalation phases, higher doses, active nausea/vomiting/abdominal pain, known diabetic gastroparesis, bowel dysmotility, Parkinsons disease, obesity, gastroesophageal reflux, opioid use, hyperglycaemia, or urgent/emergency procedures
Chris Serres: you know, something like one in eight Americans now, take GLP-1s to address, concerns around weight, obesity and diabetes
Being a large peptide molecule and hence difficult to absorb, the bioavailability of semaglutide dosed orally is relatively low [25, 26]
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