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Hydrogels have been designed and synthesized loaded with a miR-223-5p mimic, which promotes the polarization of macrophages to M2-type macrophages in wound tissue and upregulates the expression of the anti-inflammatory gene Arg-1 and downregulates the expression of TNF, IL-1, and IL-6 (Saleh et al., 2019)
Reversible inactivation by hydrogen peroxide
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Lipoic acid decreases oxygen free radicals, which in excess promote endothelial dysfunction and contribute to diabetes, high blood pressure, and cardiovascular disease (Xiang 2008
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