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In healthy cells, FOXO4 sequesters p53 in the nucleus

Glossary CKD Chronic kidney disease CVD Cardiovascular disease FDA Food and Drug Administration GLP-1 Glucagon-like peptide-1 GLP-1s Glucagon-like peptide-1 receptor agonists HF Heart failure MASH Metabolic dysfunction-associated steatohepatitis OA Osteoarthritis OSA Obstructive sleep apnea PAD Peripheral arterial disease SC Subcutaneous T2DM Type 2 diabetes mellitus U.S

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This elevated baseline body weight and helped buffer against anticipated losses and pharmacological effect, allowing the research animals to complete the study without requiring dose holidays or protocol adjustments