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Improved circulation to extremities is a less common but notable report
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A variational principle (see the Supplementary) in conjunction with the elimination of h = 1 c 14,15 leads to a Darcy law for the velocity of the cancerous phase : where ( c ) is the derivative of the free-energy of cancerous cell-cell interactions with respect to c
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2 The immunotherapeutic landscape of osteosarcoma: challenges and resistance mechanisms 2.1 The immunosuppressive TME The osteosarcoma TME is a complex ecosystem comprising malignant cells, stromal cells, immune infiltrates, and ECM components embedded within a mineralized bone scaffold ( TAMs represent the most abundant immune cell population within the osteosarcoma TME, often accounting for over 50% of infiltrating immune cells (30)
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