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For lighter complexions, a higher concentration of pheomelanin and lower eumelanin levels are ideal

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reduced glutathione (GSH) is the active form that is able to repair oxidative damage, and oxidized glutathione (GSSG) is the inactive form that can be recycled back into GSH

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated