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Gastrointestinal Effects The most commonly reported adverse effects are gastrointestinal in nature, including: Nausea and vomiting (affecting 20-40% of patients initially, varying by agent and dose) [8] Diarrhoea or constipation Abdominal discomfort and bloating Reduced appetite In elderly patients, persistent nausea and vomiting can lead to dehydration and electrolyte imbalances more rapidly than in younger adults

In addition, acute oral toxicity experiments in mice showed that compound 8u is non-toxic and can tolerate doses up to 2000 mg/kg (Zhang et al., 2019)

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Semaglutide functions by slowing stomach emptying and signaling the brain to feel full, reducing food intake naturally