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There is no published long-term human safety data, no completed RCT, and the most-cited theoretical concern remains angiogenesis in the context of undiagnosed cancer
It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)
Types I and III apply to the skin, hair, and nails
The following information is provided solely for research protocol design and should not be construed as medical advice
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