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based on consistent formation of -helical structure in initial rounds of structure calculations in which no hydrogen bond restraints were defined), inter-molecular PRE restraints (4 non-interacting copies of the spin label to account for different spin label orientations), inter- and intra-molecular NOE restraints, and ambiguous distance restraints for residues showing CSPs upon binding
This is relatively common in elderly people
Distinct metabolic programs established in the thymus control effector functions of T cell subsets in tumor microenvironments
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