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It can also contribute to weight reduction through the central nervous system

On the other hand, increased oxidative stress can generate higher levels of ROS and reactive nitrogen species, leading to increased oxidative and nitrosative damage, mitochondrial aging, DNA damage, and maintenance of chronic inflammation [411]

After statistics, we found that the expression of these proteins decreased after PA modeling, and increased after adding berberine, while after giving GLP-1R inhibitor, this trend of berberine was inhibited (Figures 5CG)