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All GLP-1 RAs are eliminated mainly via proteolytic degradation (not renal clearance, except exenatide which has some renal excretion)

In diabetic patients, GSTT1 -null conferred higher levels of triglycerides and VLDL-cholesterol, while GSTM1 -null was associated with increased levels of fasting blood glucose, glycated hemoglobin and blood pressure

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Despite the potential for problems in the short term, we believe these drugs represent a massive market with opportunities for mid- and small-cap companies