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In preclinical work, BPC157 has been evaluated in cellbased and animal models where investigators examine structural integrity, barrier function, and responses to experimental tissue injury, strictly within controlled research settings

GHK-Cu cannot cross intact stratum corneum effectively

doi:10.3389/fendo.2023.1120533

( Wiley Online Library ) Where the evidence is still a bit thin Topical anti-wrinkle outcomes: a 2025 review on topical GHK as an anti-wrinkle peptide points out practical limitations (like stability and penetration) and highlights that clinical studies are surprisingly limited compared to how widely its promoted