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They lower cortisol (your stress hormone), support insulin sensitivity, and reduce low-grade inflammation which means: Fewer crashes and cravings Less belly fat storage Better sleep and recovery For women in their 40s and 50s on the Josie program, this shift often brings more energy and better sleep too
Each estimand carries its own placebo comparator 2.3% under the trial product estimand, 3.0% under treatment policy so the placebo arm moves in the opposite direction to the treatment arm between the two analyses
It may be more than just stress or aging
It is available now at pharmacies nationwide, with pricing starting at $25 per month with commercial insurance and $149 per month for self-pay
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