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In STEP-1, semaglutide 2.4 mg weekly produced a mean 14.9% body-weight change versus 2.4% with placebo at 68 weeks, with 15% weight loss reached by 50.5% of participants
This stays an FDA-approved maintenance level
Most protocols recommend a 37 day gap between the final semaglutide injection and the first tirzepatide dose, though exact timing depends on the patient's dose level and how their body metabolizes the first medication
This is the foundational product in the Replenza system, designed to cover the broad nutritional gaps that reduced food intake creates
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