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Search strategy and study selection We conducted a comprehensive systematic search across five electronic databases: PubMed, Embase, Web of Science, Scopus, and the Cochrane Library, as well as the Google Scholar search engine, from inception to September 30, 2025, to identify studies investigating the association between GLP-1 receptor agonists and AUD outcomes
DPP-4 Inhibitors: HbA1c Reduction & NHS Guidance DPP-4 inhibitors lower HbA1c by blocking the enzyme that breaks down incretin hormones, helping the body regulate blood sugar more effectively in type 2 diabetes
Melanocortin Agonist: Contains PT141, which acts on receptors in the central nervous system
The FDA prescribing information notes that tirzepatide delays gastric emptying and has the potential to impact the absorption of oral medications, including those with narrow therapeutic indices like levothyroxine
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