tirzepatide/semaglutide blend Maintenance therapy on semaglutide or tirzepatide Retatrutide vs Tirzepatide vs Semaglutide

Some anesthesia teams are now comfortable with shorter pauses, or no pre-op pause for low-risk procedures with normal NPO times

We also tested the effects of semaglutide on binge-like and dependence-induced alcohol drinking in male and female rats, as well as acute effects of semaglutide on spontaneous inhibitory postsynaptic currents (sIPSCs) from central amygdala (CeA) and infralimbic cortex (ILC) neurons

Common side effects include nausea and vomiting

Additionally, variations in dosing equivalence, species-specific GLP-1 receptor expression, and metabolic responsiveness further complicate the direct translation of these findings to human diseases (De Giorgi et al., 2025)