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Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
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Moreover, chronic inflammation interferes with the function of the HPG axis, disrupting the secretion of gonadotropins and indirectly affecting spermatogenesis [37, 278]
Neurons in the caudal portion of the nucleus of the solitary tract synthesize pre-proglucagon and are regarded as the principal source of GLP-1 in the brain, with projections targeting GLP-1Rs (Zheng et al., 2024)
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