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Although almost all tissues in the body have some ability to metabolize chemicals, smooth endoplasmic reticulum in the liver is the principal "metabolic clearing house" for both endogenous chemicals (e.g., cholesterol, steroid hormones, fatty acids, proteins) and exogenous substances (e.g., drugs, alcohol)
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
[3] Without intrinsic factor, dietary B12 cannot be absorbed effectively, regardless of intake levels
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