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Biochem Soc Trans (2015) 43:6216
94 MET amplification occurs in approximately 1520% of EGFR-TKIresistant cases
Primarily by peptidases in plasma, on endothelial surfaces, and within tissues, which cleave them into shorter fragments and ultimately free amino acids
Specifically, significant enrichment observed in pathways associated with energy metabolism, including tricarboxylic acid (TCA) cycle intermediates and fatty acid -oxidation and alterations in amino acid metabolism pathways, particularly those involving glutathione metabolism, emphasized the role of NAC in maintaining cellular redox homeostasis
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