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Important bidirectional communication occurs between the brain and immune system in inflammatory diseases such as RA, and circulating immune complexes can cause neuroinflammatory responses in the brain

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In the largest multicenter trial to date ( n = 144), the study protocol systematically recorded adverse events including needling pain, hematoma, bleeding, fainting, and local infection, with serious adverse events defined as those requiring hospitalization or resulting in persistent disability ( n = 60) reported no serious adverse events related to EA

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