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Increasing the dose of exenatide is not recommended in patients with an estimated glomerular filtration rate (eGFR) of 30-60 mL/min/1.73 m 2 , it is contraindicated for use in patients with an eGFR of less than 30 mL/min/1.73 m 2 (123)
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A major potential advantage of the peptide is that due to its apparent GHRH receptor specificity, it may not induce any significant change in the levels of other endocrine markers such as prolactin, insulin, cortisol, glucose, or thyroid hormones
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