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This study was supported by grants from National Natural Science Foundation of China [Grant Nos
World obesity atlas 2022
It is important to note that although DPP-4 inhibition results in a systemic increase in active GLP-1 levels, recent animal data suggest that the glycaemic effects of DPP-4 inhibition might also involve local intestinal inhibition of DPP-4 activity, activation of incretin receptors, reduced liberation of bioactive peptides and increased vagus nerve activity [12]
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