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Risk factors include occupations requiring prolonged standing, being overweight, having flat feet or high arches, tight calf muscles, and sudden increases in physical activity

16 When these criteria were updated in 2010 and 2011, the physical examination of tender points was eliminated, and a symptom severity scale and self-reported widespread pain index were added

The ensuing mechanistic study revealed that ebselen protected cells and mice models by lowering radiation-induced ROS production, followed by inhibition of lipid peroxidation, protein carbonylation, DNA damage, and ultimately apoptosis