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It is mostly used to treat cancer, cardiovascular illnesses, neurological ailments, and respiratory diseases [174,175,176]
Therefore, the combined metabolic and functional disruptions in DAAs and reactive astrocytes exacerbate neuronal dysfunction, cellular pathophysiology, and cell death, contributing to progression in CNS pathology
Mitochondrial dysfunction is a central feature of PD, with complex I of the electron transport chain being particularly affected
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