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Mechanism of Action: How MT1 Interacts with Melanocortin Receptors MT1 exerts its effects by binding to and activating melanocortin receptors, particularly MC1R, which is expressed on melanocytes
Obesity and the regulation of energy balance
Retatrutide vs Tirzepatide Tirzepatide (Mounjaro/Zepbound) adds GIP receptor activation to GLP-1, representing an intermediate step between Semaglutide and Retatrutide
A multidisciplinary expert consensus published in 2022 suggested pausing or reducing the dose of metformin therapy during initiation of a GLP-1 RA as an option to reduce GI side effects (Gorgojo-Martnez et al, 2022), although this is not widely practised in the UK
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