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The molecular consequence of SEPSECS mutations is a near-complete failure of Sec biosynthesis: without functional SEPSECS, phosphoseryl-tRNA [Ser]Sec cannot be converted to Sec-tRNA [Ser]Sec , and the synthesis of all selenoproteins is globally impaired
Common triggers include fragrances, preservatives, nickel, latex, and topical medications
Hair loss considerations Rapid weight loss from any cause can trigger telogen effluvium, a temporary form of hair shedding
A protein truncating HSD17B13 variant and protection from chronic liver disease
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